Maternal infection and immune involvement in autism

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Maternal infection and immune involvement in autism.

Recent studies have highlighted a connection between infection during pregnancy and the increased risk of autism in the offspring. Parallel studies of cerebral spinal fluid, blood and postmortem brains reveal an ongoing, hyper-responsive inflammatory-like state in many young as well as adult autism subjects. There are also indications of gastrointestinal problems in at least a subset of autisti...

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Maternal Infection During Pregnancy and Autism Spectrum Disorders.

We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal ...

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ژورنال

عنوان ژورنال: Trends in Molecular Medicine

سال: 2011

ISSN: 1471-4914

DOI: 10.1016/j.molmed.2011.03.001